- 相關(guān)推薦
化學(xué)分析員面試常見(jiàn)問(wèn)題
1、鑒別檢查在藥品質(zhì)量控制中的意義及一般雜質(zhì)檢查的主要項(xiàng)目是什么? What are the purposes of drug identification and test? What arethe usual items of drug tests?.
2、比色比濁操作應(yīng)遵循的原則是什么? What are the standard operation procedures for the clarity test?
3、試計(jì)算葡萄糖重金屬檢查中標(biāo)準(zhǔn)鉛溶液的取用量。How much of the lead standard solution should be taken for thelimit test for heavy metals in this experiment?
4、古蔡氏試砷法中所加各試劑的作用與操作注意點(diǎn)是什么? What precautions should be taken for the limit test for arsenic(AppendixVIII J， method 1)? And what is thefunction for each of the test solutions added?
5、根據(jù)樣品取用量、雜質(zhì)限量及標(biāo)準(zhǔn)砷溶液的濃度，計(jì)算標(biāo)準(zhǔn)砷溶液的取用量。Figure out the amount of the arsenic standard solution that shouldbe taken for the limit test for arsenic(Appendix VIII J， method 1) (0.0001%) inthis experiment with the specified quantity of2.0 gof sample.
6、熾灼殘?jiān)鼫y(cè)定的成敗關(guān)鍵是什么？什么是恒重？What is the key step during the determination of residue onignition? What does ‘ignite or dry to constant weight’ mean?
7、鹽酸普魯卡因的鑒別原理是什么？What are the principles of the identification of ProcaineHydrochloride.
8、鹽酸普魯卡因注射液中為什么要檢查對(duì)氨基苯甲酸？Why is the limit of 4-aminobenzoic acid tested for ProcaineHydrochloride?
9、 薄層色譜法檢查藥物中有關(guān)物質(zhì)的方法通常有哪幾種類(lèi)型?本實(shí)驗(yàn)屬于哪種?與其它方法有何異同點(diǎn)? How many kinds of the limit tests for related compounds arethere? What are the differences between them? Which one is used for the limittest of 4-amino-benzoic acid in ProcaineHydrochloride Injection?
10、醋酸氫化可的松的鑒別原理是什么？What are the principles of the identification of hydrocortisoneacetate?
11、 甾體激素中“其它甾體”檢查的意義和常用方法是什么？What are the commonly used method for and the significance of thelimit test for other steroids for the steroidal drugs?
12、 哪類(lèi)甾體激素可與四氮唑藍(lán)產(chǎn)生反應(yīng)，是結(jié)構(gòu)中的何種基團(tuán)參與了反應(yīng)，反應(yīng)式是什么？What kind of steroidal drugs can react with the alkalinetetrazolium blue TS? What is the chemicalreaction equation?
13、 氯貝丁酯的鑒別原理是什么？What are the principles of the identification of clofibrate?
14、 氯貝丁酯中為什么要檢查對(duì)氯酚？其方法及原理是什么？Why is the limit ofp-Chlorophenol tested for clofibrate?What kind of method is employed for the test and what is the principle?
15、 氣相色譜法檢查雜質(zhì)有哪些方法，試比較各種方法的特點(diǎn)？How many types of methods are there for the test of relatedcompounds by the gas chromatography? What are the differences between them?
16、 抗生素類(lèi)藥物的鑒別和檢查有何特點(diǎn)？What are the characteristics for the identification and tests ofantibiotics?
17、 鈉鹽的焰色反應(yīng)應(yīng)注意什么？What precautions should be taken during the flame reaction ofsodium salts?
18、 本品吸收度檢查的意義是什么？What is the purpose of the light absorption tests for benzylpenicillinsodium?
19、 藥物晶型測(cè)定的常用方法有哪些，各有什么特點(diǎn)？What are the commonly used methods for the test of polymorphism?And what are the characteristics of each of them?
20、 吸收系數(shù)測(cè)定方法與要求？What are the standard operation procedures for the establishmentof specific absorbance?
21、 寫(xiě)出異煙肼與溴酸鉀的滴定反應(yīng)式和滴定度的計(jì)算過(guò)程。What are the chemical reaction equations and the equivalentrelationship for the assay of isoniazid bythe method of potassium bromate (0.01667mol/L) VS titration.
22、 當(dāng)游離肼不合格時(shí)，對(duì)測(cè)定有何影響？If the test for the free hydrazine does not comply， what will happen to theresults of the assay of isoniazid by the potassium bromate titration?
23、 葡萄糖旋光度法測(cè)定含量時(shí)，為什么要加氨試液并放置后進(jìn)行測(cè)定？Why should the ammonia TS be added to the solution which is thenallowed to stand for 10 minutes in the assay of glucose by the method ofoptical rotation?
24、 推算出旋光度法測(cè)定葡萄糖含量時(shí)的計(jì)算系數(shù)2.0852；Figure out the coefficient of2.0852 inthe calculation of the glucose content inthe assay of glucose by the method of optical rotation.
25、 寫(xiě)出剩余碘量法測(cè)定葡萄糖化學(xué)反應(yīng)過(guò)程。Figure out the chemical reaction equations and the equivalentrelationship for the assay of glucoseby the method of iodine titration.
26、 哪些巴比妥藥物能用銀量法進(jìn)行含量測(cè)定？為什么？What kind of barbitals can be assayed by the potentiometrictitration with silver nitrate?
27、 水溶液銀量法電位滴定中采用的電極系統(tǒng)是什么？What type of electrode pairs should beused for the potentiometric titrationwith silver nitrate?
28、 寫(xiě)出高氯酸滴定硫酸奎尼丁的滴定反應(yīng)式并計(jì)算滴定度？Figureout the chemical reaction equation of Quinidine Sulfate with per-chloric acid andthe equivalent relationship.
29、 非水滴定法中常見(jiàn)酸根的影響如何消除？How to circumvent theinterferences of other acid during the non-aqueoustitration of basic drugs with perchloric acid?
30、 非水滴定的注意事項(xiàng)有哪些？常用終點(diǎn)指示方法是什么？What precautions should be taken during thenon-aqueous titration? What are the commonly used methods for the end-pointindicating during the titration?
31、 寫(xiě)出亞硝酸鈉滴定鹽酸普魯卡因的滴定反應(yīng)式并計(jì)算滴定度？Figure out the chemical reaction equation of ProcaineHydrochloride with sodium nitrite and the equivalent relationship.
32、 亞硝酸鈉滴定的適用范圍是什么？注意事項(xiàng)有哪些？常用終點(diǎn)指示方法有哪些？What type of compounds may be assayedwith the dead-stop titration by sodiumnitrite? What precautions should be taken in the dead-stop titration? What other end-point indicating methods arethere?
33、 氧瓶燃燒操作的注意事項(xiàng)有哪些？ What precautions should betaken to conduct the oxygen flask combustion method?
34、 如何選擇氧瓶燃燒法的吸收溶液？Howto select the absorbing liquid for theoxygen flask combustion method?
35、 氧瓶燃燒法在藥物分析中的主要應(yīng)用有哪些？What are the major applications of the oxygen flask combustion method in the analysis of drugs?
36、 為什么供肌內(nèi)注射用肌甘注射液含量測(cè)定時(shí)必須先進(jìn)行紙色譜分離？Why is the pa-pe-r chromatographic separation used for the assay ofintramascular injection of inosine?
37、 本測(cè)定法平行試驗(yàn)相對(duì)誤差的限度應(yīng)該小于多少？What is the requirement of the precision of theassay of inosine for intramascular injection?
38、 各國(guó)藥典中維生素A的含量測(cè)定為什么都采用分光光度方法？Why arethe spectrophotometric assay method used for the assay of Vitamin A in all thepharmacopoeias?
39、 試推導(dǎo)出各種不同情況下維生素A含量測(cè)定的計(jì)算式。Figureout all the equations for the calculation of the content of Vitamin A
40、 氣相色譜測(cè)定維生素E含量時(shí)為什么使用內(nèi)標(biāo)法？Why is the internalreference standard method employed for the assay of Vitamin E by GC?
41、 試述氣相色譜法的特點(diǎn)及分析適用范圍。Givean explanation of the features and applications of GC method?
42、 維生素E含量測(cè)定的其它方法有哪些？各有什么特點(diǎn)？What other methods are there for the assay of Vitamin E?
43、 阿司匹林原料藥物與及阿司匹林腸溶片在質(zhì)量檢驗(yàn)方面有哪些不同之處？為何不同？What is the differencebetween the assay of aspirin and its enteric-coated tablets?
44、 阿司匹林腸溶片釋放度檢查中為什么要更換溶劑？Givean explanation of the purpose of the solvent changing during the drug release test of aspirin enteric-coated tablets.
45、 氫溴酸東莨菪堿的鑒別原理是什么？What are the chemicalreaction characteristics of tropane alkaloids?
46、 氫溴酸東莨菪堿片含量測(cè)定的方法與原理是什么？Whatkind of method is employed for the assay of scopolamine hydrobromide tablets?
47、 氫溴酸東莨菪堿片含量均勻度檢查的意義是什么？Why isthe content uniformity tested for the scopolamine hydrobromide tablets?
48、 本品中甲苯咪唑的含量為什么可以用分光光度法測(cè)定？Whycan the content of mebendazole of this compound tablet be assayed by thespectrophotometric method?
49、 本品中鹽酸左旋咪唑含量測(cè)定時(shí)，為什么甲苯咪唑沒(méi)有干擾？Why does mebendazole not interferewith the titration of levamisole hydrochloride in chloroform?
50、 分別說(shuō)明本品中磺胺甲噁唑和甲氧芐啶雙波長(zhǎng)法含量測(cè)定時(shí)波長(zhǎng)選擇的依據(jù)；Give an explanation of the basis of the wavelength selection forthe determination of sulfamethoxazole and trimethoprim， respectively.
51、 為何甲氧芐啶含量測(cè)定時(shí)供試液的稀釋倍數(shù)與磺胺甲噁唑測(cè)定時(shí)的要不同？Why is the more diluted solution usedfor the assay of trimethoprim than that for sulfamethoxazole?
52、 本品HPLC法檢驗(yàn)色譜系統(tǒng)適用性試驗(yàn)有什么意義？What is the systemsuitability test of the HPLC method? Give an explanation of theimportance of the system suitabilitytest of the HPLC method during the assay and the test of relatedsubstances.
53、 藥品含量以干燥品計(jì)算或無(wú)水物計(jì)算有何不同？What is the difference between thecontents of drugs when it is calculated on the anhydrous basis and on the dried basis?
54、 寫(xiě)出鹽酸克侖特中2，4-二硝基苯肼鑒定的化學(xué)反應(yīng)式。Whatare the complete chemical processes of the identification of clenbuterolhydrochloride by 2,4-dinitrophenyl hydrazine.
55、 鹽酸克侖特中總氯量測(cè)定的滴定方法是什么？滴定過(guò)程中加硝基苯并強(qiáng)力振搖的目的是什么？What kind of titration method isemployed for the total chloride test forclenbuterol hydrochloride? What is the purpose of the addition of 3ml of nitrobenzene and shaking vigorously?
56、 鹽酸克侖特含量測(cè)定采用的永停滴定法的原理是什么？有哪些注意事項(xiàng)？ What is the principle of potentio-metric titration for the assayof clenbuterol hydrochloride? What precautions should be taken during the titration?
57、 試述抗生素藥物有關(guān)物質(zhì)檢查的意義？What is the importance of the test of related substances for antibiotics.
58、 頭孢克洛水分測(cè)定的意義？What is the purpose for the test andcontrol of water content for antibiotics?
59、 抗生素藥物含量或效價(jià)測(cè)定的方法有哪些？各有什么特點(diǎn)？Whatother methods are there for the assay of antibiotics? Give an explanation ofthe characteristics of each method.
60、 槐花的主要化學(xué)成分有哪些？What kind of chemicals are there in theFlos Sophorae?
61、 藥材浸出測(cè)定方法中，冷浸法與熱浸法各有什么特點(diǎn)？水浸出物與醇浸出物有什么區(qū)別？What is the difference between the hot and cold extraction methodsas described under the determination of extractives？What is the differencebetween the ethanol-soluble and water-soluble extractives？
62、 槐花與鎂粉-鹽酸反應(yīng)鑒別的化合物的類(lèi)別是什么？反應(yīng)原理是什么？What kind of compounds are identified by the color reaction with asmall quantity of magnesium powder and 2~3 drops of hydrochloric acid？What are the reactionprocesses？
63、 槐花比色法含量測(cè)定的原理是什么？先加乙醚加熱回流提取的目的是什么？ What is the principle of the photometric assay of this drug？What is the purpose of theSoxhiet's extraction with ether？
64、 石菖蒲的主要化學(xué)成分有哪些？What kinds of componentsare there in the volatile oil obtained under the Assay?
65、 石菖蒲揮發(fā)油用甲法進(jìn)行測(cè)定；若用乙法測(cè)定須加入二甲苯1.0ml，其目的是什么？The first method for the determination of volatile oil is employedfor the assay. What is the purpose for the addition of 1.0 ml of xylene if thesecond method wasemployed?
66、 供揮發(fā)油測(cè)定用的供試品，須粉碎使能通過(guò)二號(hào)至三號(hào)篩，為什么？What should be done to the drug before the determination of volatile oil?
67、 中成藥含量測(cè)定及鑒別試驗(yàn)中檢測(cè)對(duì)象的選擇原則有哪些？本品為什么選擇丹皮酚和熊果酸進(jìn)行含量測(cè)定？Whyare paeonol and ursolic acid selected for the assay of this drug? What is the principle for the assay andidentification of traditional Chinese materia medica?
68、 熊果酸含量薄層掃描法測(cè)定時(shí)，用10%硫酸乙醇噴霧顯色后，薄層板上為什么要覆蓋同樣大小的玻璃板？Why should the plate be covered with a glass plate of the samesize and fixed up with adhesive plaster in the assay of ursolic acid, after spraying with 10% solution of sulfuric acid in ethanol and heatingat105℃for 5~7 minutes to the spots clear
69、 在中成藥及中藥材的薄層色譜鑒別中何時(shí)采用對(duì)照藥材法？When should the reference drug be used for the identification of traditional Chinese materia medica?
70、 中藥材或制劑高效液相色譜測(cè)定的注意事項(xiàng)有哪些？Whatprecautions should be taken for the assay of traditional Chinese materia medica ?
71、 黃芩苷高效液相色譜含量測(cè)定中，流動(dòng)相中的冰乙酸有何作用？What kind of influence was produced by the acetic acid in themobile phase for the HPLC assay of baicalin in this drug?
72、 本法血漿蛋白干擾的消除方法是什么？常用的其它方法有哪些？各有什么特點(diǎn)？What’s the method used for the elimination of the plasma proteininterferences in this analysis? What other usual methods are there for theelimination of the plasma protein interferences? What are the respective characteristics ofthem?
73、 阿司匹林標(biāo)準(zhǔn)溶液在4℃儲(chǔ)藏的目的是什么？為什么冰凍的阿司匹林血漿樣品在冰水浴中解凍？What are the purposes to keep the ASA standard solution at4℃?Why should the frozen plasma samples be thawed in the ice-water bath?
74、 阿司匹林血漿樣品處理過(guò)程中加0.5mol/L鹽酸0.1ml的目的是什么？What are the aims of adding0.1ml of 0.5ml/L hydrochloric acid during the sample preparation?
75、 實(shí)驗(yàn)中添加內(nèi)標(biāo)物鄰甲基苯甲酸的目的是什么？Why should the MBA be added as the internal standard in the test?
76、 回收率試驗(yàn)的目的和意義是什么？What are the aims and significances of the recovery test?
【化學(xué)分析員面試常見(jiàn)問(wèn)題】相關(guān)文章：
面試常見(jiàn)問(wèn)題集合05-01
外企面試常見(jiàn)問(wèn)題04-21
醫(yī)學(xué)面試常見(jiàn)問(wèn)題03-29
博士面試常見(jiàn)問(wèn)題03-29
銷(xiāo)售面試常見(jiàn)問(wèn)題04-10
面試常見(jiàn)問(wèn)題及技巧05-18