化學(xué)化工專業(yè)考研面試問題

1、 鑒別檢查在藥品質(zhì)量控制中的意義及一般雜質(zhì)檢查的主要項目是什么? What are the purposes of drug identification and test? What are the usual items of drug tests?.

2、 比色比濁操作應(yīng)遵循的原則是什么? What are the standard operation procedures for the clarity test?

3、 試計算葡萄糖重金屬檢查中標(biāo)準(zhǔn)鉛溶液的取用量。How much of the lead standard solution should be taken for the limit test for heavy metals in this experiment?

4、 古蔡氏試砷法中所加各試劑的作用與操作注意點是什么? What precautions should be taken for the limit test for arsenic(Appendix VIII J， method 1)? And what is the function for each of the test solutions added?

5、 根據(jù)樣品取用量、雜質(zhì)限量及標(biāo)準(zhǔn)砷溶液的濃度，計算標(biāo)準(zhǔn)砷溶液的取用量。Figure out the amount of the arsenic standard solution that should be taken for the limit test for arsenic(Appendix VIII J， method 1) (0.0001%) in this experiment with the specified quantity of 2.0 g of sample.

6、 熾灼殘渣測定的成敗關(guān)鍵是什么？什么是恒重？What is the key step during the determination of residue on ignition? What does ‘ignite or dry to constant weight’ mean?

7、 鹽酸普魯卡因的鑒別原理是什么？What are the principles of the identification of Procaine Hydrochloride.

8、 鹽酸普魯卡因注射液中為什么要檢查對氨基苯甲酸？Why is the limit of 4-aminobenzoic acid tested for Procaine Hydrochloride?

9、 薄層色譜法檢查藥物中有關(guān)物質(zhì)的方法通常有哪幾種類型?本實驗屬于哪種?與其它方法有何異同點? How many kinds of the limit tests for related compounds are there? What are the differences between them? Which one is used for the limit test of 4-amino-benzoic acid in Procaine Hydrochloride Injection?

10、 醋酸氫化可的松的鑒別原理是什么？What are the principles of the identification of hydrocortisone acetate?

11、 甾體激素中“其它甾體”檢查的意義和常用方法是什么？What are the commonly used method for and the significance of the limit test for other steroids for the steroidal drugs?

12、 哪類甾體激素可與四氮唑藍產(chǎn)生反應(yīng)，是結(jié)構(gòu)中的何種基團參與了反應(yīng)，反應(yīng)式是什么？What kind of steroidal drugs can react with the alkaline tetrazolium blue TS? What is the chemical reaction equation?

13、 氯貝丁酯的鑒別原理是什么？What are the principles of the identification of clofibrate?

14、 氯貝丁酯中為什么要檢查對氯酚？其方法及原理是什么？Why is the limit of p-Chlorophenol tested for clofibrate? What kind of method is employed for the test and what is the principle?

15、 氣相色譜法檢查雜質(zhì)有哪些方法，試比較各種方法的特點？How many types ofmethods are there for the test of related compounds by the gas chromatography? What are the differences between them?

16、 抗生素類藥物的鑒別和檢查有何特點？What are the characteristics for theidentification and tests of antibiotics?

17、 鈉鹽的焰色反應(yīng)應(yīng)注意什么？What precautions should be taken during the flamereaction of sodium salts?

18、 本品吸收度檢查的意義是什么？What is the purpose of the light absorption tests for

benzylpenicillin sodium?

19、 藥物晶型測定的常用方法有哪些，各有什么特點？What are the commonly usedmethods for the test of polymorphism? And what are the characteristics of each of them?

20、 吸收系數(shù)測定方法與要求？What are the standard operation procedures for theestablishment of specific absorbance?

21、 寫出異煙肼與溴酸鉀的滴定反應(yīng)式和滴定度的計算過程。What are the chemicalreaction equations and the equivalent relationship for the assay of isoniazid by the method of potassium bromate (0.01667 mol/L) VS titration.

22、 當(dāng)游離肼不合格時，對測定有何影響？If the test for the free hydrazine does notcomply， what will happen to the results of the assay of isoniazid by the potassium bromate titration?

23、 葡萄糖旋光度法測定含量時，為什么要加氨試液并放置后進行測定？Why should theammonia TS be added to the solution which is then allowed to stand for 10 minutes in the assay of glucose by the method of optical rotation?

24、 推算出旋光度法測定葡萄糖含量時的計算系數(shù)2.0852；Figure out the coefficient of2.0852 in the calculation of the glucose content in the assay of glucose by the method of optical rotation.

25、 寫出剩余碘量法測定葡萄糖化學(xué)反應(yīng)過程。Figure out the chemical reactionequations and the equivalent relationship for the assay of glucose by the method of iodine titration.

26、 哪些巴比妥藥物能用銀量法進行含量測定？為什么？What kind of barbitals can beassayed by the potentiometric titration with silver nitrate?

27、 水溶液銀量法電位滴定中采用的電極系統(tǒng)是什么？What type of electrode pairsshould be used for the potentiometric titration with silver nitrate?

28、 寫出高氯酸滴定硫酸奎尼丁的滴定反應(yīng)式并計算滴定度？Figure out the chemicalreaction equation of Quinidine Sulfate with perchloric acid and the equivalentrelationship.

29、 非水滴定法中常見酸根的影響如何消除？How to circumvent the interferences ofother acid during the non-aqueous titration of basic drugs with perchloric acid?

30、 非水滴定的注意事項有哪些？常用終點指示方法是什么？What precautions shouldbe taken during the non-aqueous titration? What are the commonly used methods for the end-point indicating during the titration?

31、 寫出亞硝酸鈉滴定鹽酸普魯卡因的滴定反應(yīng)式并計算滴定度？Figure out thechemical reaction equation of Procaine Hydrochloride with sodium nitrite and the equivalent relationship.

32、 亞硝酸鈉滴定的適用范圍是什么？注意事項有哪些？常用終點指示方法有哪些？What type of compounds may be assayed with the dead-stop titration by sodium nitrite? What precautions should be taken in the dead-stop titration? What other end-point indicating methods are there?

33、 氧瓶燃燒操作的注意事項有哪些？ What precautions should be taken to conduct theoxygen flask combustion method?

34、 如何選擇氧瓶燃燒法的吸收溶液？How to select the absorbing liquid for the oxygenflask combustion method?

35、 氧瓶燃燒法在藥物分析中的主要應(yīng)用有哪些？What are the major applications of theoxygen flask combustion method in the analysis of drugs?

36、 為什么供肌內(nèi)注射用肌甘注射液含量測定時必須先進行紙色譜分離？Why is thepa-pe-r chromatographic separation used for the assay of intramascular injection of inosine?

37、 本測定法平行試驗相對誤差的限度應(yīng)該小于多少？What is the requirement of theprecision of the assay of inosine for intramascular injection?

38、 各國藥典中維生素A的含量測定為什么都采用分光光度方法？ Why are thespectrophotometric assay method used for the assay of Vitamin A in all the pharmacopoeias?

39、 試推導(dǎo)出各種不同情況下維生素A含量測定的計算式。Figure out all the equations forthe calculation of the content of Vitamin A

40、 氣相色譜測定維生素E含量時為什么使用內(nèi)標(biāo)法？Why is the internal referencestandard method employed for the assay of Vitamin E by GC?

41、 試述氣相色譜法的特點及分析適用范圍。Give an explanation of the features andapplications of GC method?

42、 維生素E含量測定的其它方法有哪些？各有什么特點？What other methods arethere for the assay of Vitamin E?

43、 阿司匹林原料藥物與及阿司匹林腸溶片在質(zhì)量檢驗方面有哪些不同之處？為何不同？What is the difference between the assay of aspirin and its enteric-coated tablets?

44、 阿司匹林腸溶片釋放度檢查中為什么要更換溶劑？Give an explanation of thepurpose of the solvent changing during the drug release test of aspirin enteric-coated tablets.

45、 氫溴酸東莨菪堿的鑒別原理是什么？What are the chemical reaction characteristicsof tropane alkaloids?

46、 氫溴酸東莨菪堿片含量測定的方法與原理是什么？What kind of method is employedfor the assay of scopolamine hydrobromide tablets?

47、 氫溴酸東莨菪堿片含量均勻度檢查的意義是什么？Why is the content uniformitytested for the scopolamine hydrobromide tablets?

48、 本品中甲苯咪唑的含量為什么可以用分光光度法測定？Why can the content ofmebendazole of this compound tablet be assayed by the spectrophotometric method?

49、 本品中鹽酸左旋咪唑含量測定時，為什么甲苯咪唑沒有干擾？Why doesmebendazole not interfere with the titration of levamisole hydrochloride in chloroform?

50、 分別說明本品中磺胺甲噁唑和甲氧芐啶雙波長法含量測定時波長選擇的依據(jù)；Give anexplanation of the basis of the wavelength selection for the determination of sulfamethoxazole and trimethoprim， respectively.

51、 為何甲氧芐啶含量測定時供試液的稀釋倍數(shù)與磺胺甲噁唑測定時的要不同？Why isthe more diluted solution used for the assay of trimethoprim than that for sulfamethoxazole?

52、 本品HPLC法檢驗色譜系統(tǒng)適用性試驗有什么意義？What is the system suitabilitytest of the HPLC method? Give an explanation of the importance of the system suitability test of the HPLC method during the assay and the test of related substances.

53、 藥品含量以干燥品計算或無水物計算有何不同？What is the difference between thecontents of drugs when it is calculated on the anhydrous basis and on the dried basis?

54、 寫出鹽酸克侖特中2，4-二硝基苯肼鑒定的化學(xué)反應(yīng)式。What are the completechemical processes of the identification of clenbuterol hydrochloride by 2,4-dinitrophenyl hydrazine.

55、 鹽酸克侖特中總氯量測定的滴定方法是什么？滴定過程中加硝基苯并強力振搖的目的是什么？What kind of titration method is employed for the total chloride test for clenbuterol hydrochloride? What is the purpose of the addition of 3 ml of nitrobenzene and shaking vigorously?

56、 鹽酸克侖特含量測定采用的永停滴定法的原理是什么？有哪些注意事項？ What isthe principle of potentio-metric titration for the assay of clenbuterol hydrochloride? What precautions should be taken during the titration?

57、 試述抗生素藥物有關(guān)物質(zhì)檢查的意義？What is the importance of the test of related

substances for antibiotics.

58、 頭孢克洛水分測定的意義？What is the purpose for the test and control of wate  content for antibiotics?

59、 抗生素藥物含量或效價測定的方法有哪些？各有什么特點？What other methods arethere for the assay of antibiotics? Give an explanation of the characteristics of each method.

60、 槐花的主要化學(xué)成分有哪些？What kind of chemicals are there in the FlosSophorae?

61、 藥材浸出測定方法中，冷浸法與熱浸法各有什么特點？水浸出物與醇浸出物有什么區(qū)別？What is the difference between the hot and cold extraction methods as described under the determination of extractives？What is the difference between the ethanol-soluble and water-soluble extractives？

62、 槐花與鎂粉-鹽酸反應(yīng)鑒別的化合物的類別是什么？反應(yīng)原理是什么？What kind ofcompounds are identified by the color reaction with a small quantity of magnesium powder and 2~3 drops of hydrochloric acid？What are the reaction processes？

63、 槐花比色法含量測定的原理是什么？先加乙醚加熱回流提取的目的是什么？ What isthe principle of the photometric assay of this drug？What is the purpose of the Soxhiet's extraction with ether？

64、 石菖蒲的主要化學(xué)成分有哪些？What kinds of components are there in the volatileoil obtained under the Assay?

65、 石菖蒲揮發(fā)油用甲法進行測定；若用乙法測定須加入二甲苯1.0ml，其目的是什么？The first method for the determination of volatile oil is employed for the assay. What is the purpose for the addition of 1.0 ml of xylene if the second method was employed?

66、 供揮發(fā)油測定用的供試品，須粉碎使能通過二號至三號篩，為什么？What should bedone to the drug before the determination of volatile oil?

67、 中成藥含量測定及鑒別試驗中檢測對象的選擇原則有哪些？本品為什么選擇丹皮酚和熊果酸進行含量測定？Why are paeonol and ursolic acid selected for the assay of this drug? What is the principle for the assay and identification of traditional Chinese materia medica?

68、 熊果酸含量薄層掃描法測定時，用10%硫酸乙醇噴霧顯色后，薄層板上為什么要覆蓋同樣大小的玻璃板？Why should the plate be covered with a glass plate of the same size and fixed up with adhesive plaster in the assay of ursolic acid, after spraying with 10% solution of sulfuric acid in ethanol and heating at 105℃ for 5~7 minutes to the spots clear

69、 在中成藥及中藥材的薄層色譜鑒別中何時采用對照藥材法？When should thereference drug be used for the identification of traditional Chinese materia medica?

70、 中藥材或制劑高效液相色譜測定的注意事項有哪些？What precautions should betaken for the assay of traditional Chinese materia medica ?

71、 黃芩苷高效液相色譜含量測定中，流動相中的冰乙酸有何作用？What kind ofinfluence was produced by the acetic acid in the mobile phase for the HPLC assay ofbaicalin in this drug?

72、 本法血漿蛋白干擾的消除方法是什么？常用的其它方法有哪些？各有什么特點？What’s the method used for the elimination of the plasma protein interferences in this analysis? What other usual methods are there for the elimination of the plasma protein interferences? What are the respective characteristics of them?

73、 阿司匹林標(biāo)準(zhǔn)溶液在4℃儲藏的目的是什么？為什么冰凍的阿司匹林血漿樣品在冰水浴中解凍？What are the purposes to keep the ASA standard solution at 4℃? Why should the frozen plasma samples be thawed in the ice-water bath?

74、 阿司匹林血漿樣品處理過程中加0.5mol/L鹽酸0.1ml的目的是什么？What are theaims of adding 0.1ml of 0.5ml/L hydrochloric acid during the sample preparation?

75、 實驗中添加內(nèi)標(biāo)物鄰甲基苯甲酸的目的是什么？Why should the MBA be added asthe internal standard in the test?

76、 回收率試驗的目的和意義是什么？What are the aims and significances of therecovery test?

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